منابع مشابه
Connecting Mitochondria, Metabolism, and Stem Cell Fate
As sites of cellular respiration and energy production, mitochondria play a central role in cell metabolism. Cell differentiation is associated with an increase in mitochondrial content and activity and with a metabolic shift toward increased oxidative phosphorylation activity. The opposite occurs during reprogramming of somatic cells into induced pluripotent stem cells. Studies have provided e...
متن کاملCarbohydrate and Lactate Metabolism
Van Hall, G., J. A. L. Calbet, H. Søndergaard, and B. Saltin. Similar carbohydrate but enhanced lactate utilization during exercise after 9 wk of acclimatization to 5,620 m. Am J Physiol Endocrinol Metab 283: E1203–E1213, 2002. First published July 30, 2002; 10.1152/ajpendo. 00134.2001.—We hypothesized that reliance on lactate as a means of energy distribution is higher after a prolonged period...
متن کاملLactate metabolism by Veillonella parvula.
A strain of Veillonella parvula M4, which grows readily in lactate broth without a requirement for carbon dioxide, has been isolated from the oral cavity. Anaerobic, washed cells of this organism fermented sodium lactate to the following products (moles/100 moles of lactate): propionate, 66; acetate, 40; carbon dioxide, 40; and hydrogen, 14. Cells grew readily in tryptone-yeast extract broth wi...
متن کاملEnergy metabolism in adult neural stem cell fate.
The adult mammalian brain contains a population of neural stem cells that can give rise to neurons, astrocytes, and oligodendrocytes and are thought to be involved in certain forms of memory, behavior, and brain injury repair. Neural stem cell properties, such as self-renewal and multipotency, are modulated by both cell-intrinsic and cell-extrinsic factors. Emerging evidence suggests that energ...
متن کاملIRF4 Couples Anabolic Metabolism to Th1 Cell Fate Determination
Anabolic metabolism in lymphocytes promotes plasmablast and cytotoxic T cell differentiation at the expense of self-renewal. Heightened expression and function of the transcription factor IFN regulatory factor 4 (IRF4) accompany enhanced anabolic induction and full commitment to functional differentiation in B cells and CD8+ T cells. In this study, we used a genetic approach to determine whethe...
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ژورنال
عنوان ژورنال: Frontiers in Physiology
سال: 2020
ISSN: 1664-042X
DOI: 10.3389/fphys.2020.610983